Evolutionary Origins of Enteric Hepatitis Viruses

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Enteric hepatitis viruses

The term “hepatitis viruses” refers to a diverse group of viruses all of which have the human liver as the primary target of replication and give rise to hepatitis or inflammation of the liver. Their replication may result in mass destruction of liver cells. Consequences include failure of the liver to fulfil basic functions such as removal of bilirubin from the circulatory blood system. Biliru...

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Enteric hepatitis viruses

Hepatitis viruses are infectious agents that can infect liver and cause inflammation. The infection triggers immune response against infected cells that leads to the destruction of hepatic cells. This destruction has two consequences: leaking ALT and AST liver enzymes which increases during the course of disease and accumulation of bilirubin- a red pigmented compound released from dead red cell...

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Enteric Hepatitis Viruses

Background The term ‘‘jaundice’’ was used as early as in the ancient Greece when Hippocrates described an illness probably corresponding to a viral hepatitis. However, it was not until the beginning of the twentieth century AU :1 when a form of hepatitis was associated to an infectious disease occurring in epidemics and the term ‘‘infectious hepatitis’’ was established. Later on in the early 19...

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Evolutionary origins of human herpes simplex viruses 1 and 2.

Herpesviruses have been infecting and codiverging with their vertebrate hosts for hundreds of millions of years. The primate simplex viruses exemplify this pattern of virus-host codivergence, at a minimum, as far back as the most recent common ancestor of New World monkeys, Old World monkeys, and apes. Humans are the only primate species known to be infected with two distinct herpes simplex vir...

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Evolutionary origins of hepatitis A virus in small mammals.

Hepatitis A virus (HAV) is an ancient and ubiquitous human pathogen recovered previously only from primates. The sole species of the genus Hepatovirus, existing in both enveloped and nonenveloped forms, and with a capsid structure intermediate between that of insect viruses and mammalian picornaviruses, HAV is enigmatic in its origins. We conducted a targeted search for hepatoviruses in 15,987 ...

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ژورنال

عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine

سال: 2018

ISSN: 2157-1422

DOI: 10.1101/cshperspect.a031690